Difference between revisions of "Biomechanical Brain Simulation by FEA"
From hpcwiki
| Line 8: | Line 8: | ||
== Summary == | == Summary == | ||
| − | . | + | Traumatic brain injuries (TBI) are related to strong angular accelerations/deaccelerations causing extreme strain/stress values along brain tissues. This can result in the affectation of wide intracraneal structures by mechanical damage, hemorragies and inflamation processes, particulary, in the axonal tracks. This set of alterations are called diffuse axonal injury that is behind severe conditions such as loss-of-consciousness in vegetative state/unresponsive wakefulness and severe disability after mild TBI. |
| + | |||
| + | The assesment of the injury and the patient prognosis in these conditions could be enhanced by using computational models reproducing the dynamics of the cerebral tissue damage (ref). In this work, we propose an specific finite element-based (FEA) model to study the biomechanical properties of axonal track damage related to the severe grading of diffuse axonal injury (Adams 1989 et al.). In particular, we aim to model (1) grey-white matter interfaces, (2) corpus callosum damage and (3) brain stem damage. | ||
== Method overview == | == Method overview == | ||
| Line 16: | Line 18: | ||
== Results (Expected) == | == Results (Expected) == | ||
| − | * Method conference. | + | * Method conference. Model proposal. |
| − | * Journal article. Complete | + | * Journal article. Complete model and application to clinical data. |
| + | |||
| + | == References == | ||
| + | |||
| + | Histopathology. 1989 Jul;15(1):49-59. Diffuse axonal injury in head injury: definition, diagnosis and grading. | ||
| + | Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. | ||
Revision as of 12:23, 26 August 2013
Contents |
People
- Manuel Mejia
- Angelica Ramirez
- Francisco Gómez
- Hugo Franco
Summary
Traumatic brain injuries (TBI) are related to strong angular accelerations/deaccelerations causing extreme strain/stress values along brain tissues. This can result in the affectation of wide intracraneal structures by mechanical damage, hemorragies and inflamation processes, particulary, in the axonal tracks. This set of alterations are called diffuse axonal injury that is behind severe conditions such as loss-of-consciousness in vegetative state/unresponsive wakefulness and severe disability after mild TBI.
The assesment of the injury and the patient prognosis in these conditions could be enhanced by using computational models reproducing the dynamics of the cerebral tissue damage (ref). In this work, we propose an specific finite element-based (FEA) model to study the biomechanical properties of axonal track damage related to the severe grading of diffuse axonal injury (Adams 1989 et al.). In particular, we aim to model (1) grey-white matter interfaces, (2) corpus callosum damage and (3) brain stem damage.
Method overview
Data sources
Results (Expected)
- Method conference. Model proposal.
- Journal article. Complete model and application to clinical data.
References
Histopathology. 1989 Jul;15(1):49-59. Diffuse axonal injury in head injury: definition, diagnosis and grading. Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR.
